Lidia Bastianich, one of my favorite chefs, has two great places (her son owns a couple with Mario Batali).
Theatre location but if you go after the theatre crowd, easier to get reservations and well worth it.
Becco.
http://www.becco-nyc.com/
Good rustic, true Italian food.
Uptown
Felidia
http://www.felidia-nyc.com/
Much more a high dining experience with very cultural meats. Fantastic.
GO!!!!