I have a healthy grudge against my older brother, the main abuser in my life. I say healthy because it doesn't consume me, and because he is still someone who is unrepentant and unsafe. He want's nothing to do with me now, so it really works out well since that is mutual.
As for friendships, I can't say I have had many that are with crazy toxic people. I tend to have for the most part healthy friends; it's some of the people I have been romantic with in one form or another who have been really toxic. I am much better now at spotting that early on and steering clear of them.